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New PBS listings!
Jul 02, 2021

Despite a global pandemic, new data relating to oncology treatments continues to be published, and it seems that this is increasingly translating into improved drug access here in Australia.

As oncologists, we are always considering the best treatment option for a patient. Whilst most ‘standard of care’ treatments are available and reimbursed on the PBS system, this is not always the case. 



We’re excited that there has been a recent run of agents newly listed on the PBS, or expanded listings that enable us to access a drug or drug combination in more clinical situations. Here’s a quick look at the recent listings:

Dr Heather Francis

Ipilimumab + Nivolumab as 1st line treatment of metastatic mesothelioma

Previously combination chemotherapy was our standard first line therapy for unresectable metastatic mesothelioma, but there is now evidence that combination immunotherapy is superior in most instances, and overall pretty well tolerated. This has been approved by the PBAC (the pharmaceutical advisory committee), and we await an upcoming date for reimbursement.

 

Fulvestrant in combination with ribociclib in metastatic breast cancer, beyond first line therapy

Fulvestrant has been a treatment option for hormone positive metastatic breast cancer for many years, however has not been reimbursed until the recent listing of a generic form of the drug. Ribociclib has been available for several years for the first line treatment of metastatic hormone positive breast cancer, but is now accessible for those who have already had multiple lines of treatment.

 

Ipilimumab + nivolumab  (with chemotherapy) as 1st line treatment in metastatic squamous cell carcinoma of the lung

This is now one of many approved regimens in the first line treatment of metastatic lung cancer now. 


Bevacizumab biosimilar (Mvasi) – listed unrestricted

Bevacizumab has been used for many years in metastatic colorectal cancer, and ovarian cancer, and more recently in Glioblastoma Multiforme (stage IV glioma). PBS reimbursement has, however, previously been limited to specific scenarios. The unrestricted listing will allow oncologist to prescribe the drug according to the data, rather than being restricted by reimbursement.


- Dr Heather Francis

4th Dose COVID-19 Vaccine for Immunocompromised Patients
01 Mar, 2022
The Australian Technical Advisory Group on Immunisation (ATAGI) has approved a fourth dose of a COVID-19 vaccine for people with weakened immune systems. People aged 18 years or older with weakened immune system who received a 3-dose primary course of the COVID-19 vaccine are now recommended to receive the fourth dose ≥ 3 months after their third dose. This is expected to improve protection against symptomatic infection, serious illness, or death from COVID-19 infection.
COVID-19 Vaccine Booster Shots In Our Patients With Cancer
08 Nov, 2021
The Government and the Medical advisory group (ATAGI) have release new recommendations last week for individuals who are severely immunocompromised in regards to the COVID-19 vaccine. These recommendations will affect some (but not all) of our patients. As always, we are happy to discuss any of the recommendations further with all of our patients.
COVID-19 Vaccination FAQs July 2021
20 Jul, 2021
In the last few months, I have been inundated with many questions regarding COVID-19 vaccination and blood clots from patients and other health practitioners. In this article, I have compiled these frequently asked questions.
Astra Zeneca (AZ) vaccine safety information
26 Mar, 2021
In light of recent reports of clotting events following Astra Zeneca (AZ) vaccine in Europe - we have been frequently asked questions regarding the safety of AZ vaccine in patients with previous clot events and/or blood problems
25 Feb, 2021
Two vaccines against the coronavirus have now been approved for use in Australia, role-out of the vaccine begins this week in high-risk populations.
18 Jan, 2021
Dr Swe Myo Htet Consultant Haematologist MBBS, FRACP, FRCPA, MRCP
Blood clot disorder and long distance car-travel
02 Dec, 2020
Blood specialist, Dr. Pohan Lukito, answers frequently asked question regarding blood clot disorder and long distance car-travel
Exercise and Cancer
26 Oct, 2020
Patients with a malignancy, and in particular those receiving treatment for a malignancy, often experience fatigue. And while adequate rest is important, there has been increasing evidence over the past few years that a regular exercise programme can have a considerable benefit on this fatigue, as well and many other treatment related side effects.
13 Oct, 2020
Today (13th Oct) is World Thrombosis Day. We are raising awareness of blood clotting disorders - please find this informative article written by Dr Swe Htet. Patients - you can refer to educational material written by Thrombosis & Haemostasis society of Australia and New Zealand (THANZ) - Preventing another clot (download PDF here) More information regarding thrombosis from THANZ https://www.thanz.org.au/educationandtraining/education-training Clinicians/GPs - you can refer to the Thrombosis Quick Guide developed by our haematologists to help you manage patients with thrombosis (download PDF here) ---------------------------- 1 in 4 people are dying from conditions caused by thrombosis. Blood clotting is a biological plumber fixing a leaking blood vessel. Blood clot will save your life from bleeding if you have a cut in your finger. However, if a blood clot forms unnecessarily in blood vessels called thrombosis, it can lead to significant medical issues. Thrombosis can develop either in the arteries or veins. If there is a clot in an artery supplying the brain, that part of the brain will die leading to stroke. The same principle applies for heart attack when there is a blood clot in the coronary arteries supplying blood to the heart. Whilst many people are aware of the signs and symptoms of a heart attack or stroke, the symptoms of blood clot in the veins can be more difficult to recognized, leading to delayed presentation and treatment. Blood clot forming in the deep veins of the legs is called deep vein thrombosis (DVT). Whilst DVT in the lower limbs is not usually life-threatening, if a large clot breaks off and travels to the lung(s), it can cause blockage of blood flow into the lung(s) causing pulmonary embolism (PE) that can be extremely dangerous to patients. Symptoms of DVT in the legs can be pain, swelling or redness in the calf. Patients can present with palpitation, chest pain, and shortness of breath if there is PE. There are three main risk factors for thrombosis in the veins - immobility, sticky blood, and changes in the lining of the veins. These risks could be acquired, such as immobility during long distance travel (flights) and patients lying in bed following surgery, or specific conditions e.g. cancer that could cause blood to be “more sticky”. However, some of the risks could also be familial (passed down from families). Please speak to your doctor regarding these risks if you are concerned. These are quite different to the risk factors of arterial thrombosis; which are mainly smoking, high cholesterol, diabetes, and hypertension. Venous thrombosis can be treated with blood thinning agents. Different blood thinning agents used for venous thrombosis include Warfarin, Clexane, and more recently - Rivaroxaban and Apixaban. Main complication of blood thinning agent is bleeding. The choice and duration of blood thinning agent varies among different individuals. Please discuss this with your doctor. Blood Specialists at Ballarat Cancer Care and Haematology will be available to have further conversation regarding management of blood clots. ~ Article written by Dr Swe Htet
Cancer deaths reduce Australia wide
16 Sep, 2020
This year the annual release of cancer statistics generated quite a buzz in the cancer community. We have seen an ongoing and significant decline in the overall number of cancer deaths through Australia. Improvements in the number of deaths from lung cancer, which account for more cancer deaths than breast, prostate and colorectal cancer combined, was the main driver for this decline.
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